Gürsel Çalışkan, PhD
Dr. Gürsel Caliskan
Department of Genetics & Molecular Neurobiology
RG Synapto-Oscillopathies
I have been studying cellular and circuit-level changes in animal models of fear and anxiety via combining different approaches including electrophysiology, behaviour and pharmacogenetics (DREADDs). My current research focuses on identification of physiological and pathological alterations in the hippocampal activity patterns and their relation to modulation of hippocampal engrams in animal models of neuropsychiatric and neurodegenerative disorders. I am also interested in the impact of environmental factors and their interactions with the immune system in mediation of affective behaviour.
Education
B.Sc. in Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey 2006
M.Sc. in Medical Neurosciences, Humboldt University, Charité Medical Faculty, Berlin, Germany 2008
Dr. rer. nat. in Medical Neurosciences, Humboldt University, Charité Medical Faculty, Berlin, Germany 2015
2024
Recognizing depression as an inflammatory disease: the search for endotypes.
Steffen, Johannes; Focken, Nis; Çalışkan, Gürsel
In: American journal of physiology. Cell physiology - Bethesda, Md. : American Physiological Society, Bd. 327 (2024), Heft 1, insges. 8 S.
Recognizing depression as an inflammatory disease - the search for endotypes
Steffen, Johannes; Focken, Nis; Çalışkan, Gürsel
In: American journal of physiology. Cell physiology - Bethesda, Md. : American Physiological Society, Bd. 327 (2024), Heft 1, S. C205-C212
2023
Sex differences in anxiety and threat avoidance in GAD65 knock-out mice
Ulrich, Michelle; Pollali, Evangelia; Çalişkan, Gürsel; Stork, Oliver; Albrecht, Anne
In: Neurobiology of disease - [Amsterdam] : Elsevier, Bd. 183 (2023), Artikel 106165, insges. 12 S.
Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus
Klinger, Katharina; Ángel, Miguel; Çalışkan, Gürsel; Stork, Oliver
In: Frontiers in aging neuroscience - Lausanne : Frontiers Research Foundation, Bd. 15 (2023), Artikel 1283581, insges. 12 S.
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy
Blondiaux, Armand; Jia, Shaobo; Annamneedi, Anil; Çalişkan, Gürsel; Nebel, Jana; Montenegro-Venegas, Carolina; Wykes, Robert C.; Fejtova, Anna; Walker, Matthew C.; Stork, Oliver; Gundelfinger, Eckart D.; Dityatev, Alexander; Seidenbecher, Constanze I.
In: Neurobiology of disease - [Amsterdam] : Elsevier, Bd. 188 (2023), Artikel 106324, insges. 17 S.
Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations
Çalışkan, Gürsel; Demiray, Yunus E.; Stork, Oliver
In: European journal of neuroscience - Oxford [u.a.] : Wiley, Bd. 58 (2023), Heft 6, S. 3383-3401
Neural extracellular matrix remodeling signatures in genetic and acquired mouse models of epilepsy
Blondiaux, Armand; Jia, Shaobo; Annamneedi, Anil; Çalişkan, Gürsel; Schulze, Jana; Montenegro-Venegas, Carolina; Wykes, Robert C.; Fejtova, Anna; Walker, Matthew C.; Stork, Oliver; Gundelfinger, Eckart D.; Dityatev, Alexander; Seidenbecher, Constanze I.
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2023, insges. 42 S.
2022
Choosing memory retrieval strategies - a critical role for inhibition in the dentate gyrus
Albrecht, Anne; Müller, Iris; Weiglein, Aliće; Pollali, Evangelia; Çalişkan, Gürsel; Stork, Oliver
In: Neurobiology of Stress - Amsterdam [u.a.] : Elsevier, Bd. 20 (2022), Artikel 100474, insges. 11 S.
Antibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus
Çalişkan, Gürsel; French, Timothy; Lacalle, Sara Enrile; Angel, Miguel; Steffen, Johannes; Heimesaat, Markus M.; Dunay, Ildikò Rita; Stork, Oliver
In: Brain, behavior and immunity - Orlando, Fla. [u.a.] : Elsevier, Bd. 99 (2022), S. 203-217
Comparison of three common inbred mouse strains reveals substantial differences in hippocampal GABAergic interneuron populations and in vitro network oscillations
Caliskan, Gürsel; Demiray, Yunus Emre; Stork, Oliver
In: Authorea - Hoboken : Authorea . - 2022, insges. 22 S.
Editorial: Functional aspects of mesoscopic brain oscillations - insights from in vivo and in vitro studies
Caliskan, Gürsel; Mikulovic, Sanja; Girardeau, Gabrielle
In: Frontiers in neural circuits - Lausanne : Frontiers Research Foundation, Bd. 16 (2022), Artikel 960157, insges. 2 S.
Glucocorticoid modulation of synaptic plasticity in the human temporal cortex of epilepsy patients - does chronic stress contribute to memory impairment?
Brandner, Sebastian; Schroeter, Sarah; Caliskan, Gürsel; Salar, Seda; Kobow, Katja; Coras, Roland; Blümcke, Ingmar; Hamer, Hajo; Schwarz, Michael; Buchfelder, Michael; Maslarova, Anna
In: Epilepsia - Oxford [u.a.] : Wiley-Blackwell, Bd. 63 (2022), Heft 1, S. 209-221
Fear engrams and NPYergic circuit in the dorsal dentate gyrus determine remote fear memory generalization
Raza, Syed Ahsan; Klinger, Katharina; Ángel, Miguel; Demiray, Yunus Emre; Caliskan, Gürsel; Kreutz, Michael R.; Stork, Oliver
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2022, insges. 28 S.
Hippocampal gamma-band oscillopathy in a mouse model of fragile X syndrome
Pollali, Evangelia; Hollnagel, Jan-Oliver; Caliskan, Gürsel
In: bioRxiv beta - Cold Spring Harbor : Cold Spring Harbor Laboratory, NY . - 2021, insges. 26 S.
2021
The presynaptic scaffold protein Bassoon in forebrain excitatory neurons mediates hippocampal circuit maturation - potential involvement of TrkB signalling
Annamneedi, Anil; Ángel, Miguel; Gundelfinger, Eckart D.; Stork, Oliver; Çalişkan, Gürsel
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 22 (2021), Heft 15, Artikel 7944, insges. 15 S.
Transgenic modeling of Ndr2 gene amplification reveals disturbance of hippocampus circuitry and function
Madencioglu, Deniz A.; Çalişkan, Gürsel; Yuanxiang, Pingan; Rehberg, Kati; Demiray, Yunus E.; Kul, Emre Ufuk; Engler, Alexander; Hayani, Hussam; Bergado Acosta, Jorge R.; Kummer, Anne; Müller, Iris; Song, Inseon; Dityatev, Alexander; Kähne, Thilo; Kreutz, Michael R.; Stork, Oliver
In: iScience - Amsterdam : Elsevier, Bd. 24 (2021), Heft 8, Artikel 102868, insges. 23 S.
2020
Long-term impact of early-life stress on hippocampal plasticity - spotlight on astrocytes
Çalişkan, Gürsel; Müller, Anke; Albrecht, Anne
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International - Vol. 21.2020, 14, Art.-Nr. 4999, insgesamt 19 Seiten
2019
Depletion of dietary phytoestrogens reduces hippocampal plasticity and contextual fear memory stability in adult male mouse
Çalışkan, Gürsel; Raza, Syed Ahsan; Demiray, Yunus E.; Kul, Emre; Sandhu, Kiran V.; Stork, Oliver
In: Nutritional neuroscience - Abingdon, Oxon : Routledge, Taylor and Francis Group . - 2019 [Online first]
Persistent increase in ventral hippocampal long-term potentiation by juvenile stress - a role for astrocytic glutamine synthetase
Ivens, Sebastian; Çalışkan, Gürsel; Papageorgiou, Ismini; Cesetti, Tiziana; Malich, Ansgar; Kann, Oliver; Heinemann, Uwe; Stork, Oliver; Albrecht, Anne
In: Glia - Bognor Regis [u.a.]: Wiley-Liss, Bd. 67 (2019), 12, S. 2279-2293
2018
Hippocampal network oscillations as mediators of behavioural metaplasticity - insights from emotional learning
Çalışkan, Gürsel; Stork, Oliver
In: Neurobiology of learning and memory - Orlando, Fla.: Academic Press, 1995 . - 2018, insges. 17 S.[Online first]
Hippocampal network oscillations at the interplay between innate anxiety and learned fear
Çalışkan, Gürsel; Stork, Oliver
In: Psychopharmacology - Berlin: Springer, Bd. 236 (2018), 1, S. 321-338
Ablation of the presynaptic organizer Bassoon in excitatory neurons retards dentate gyrus maturation and enhances learning performance
Annamneedi, Anil; Çalişkan, Gürsel; Müller, Sabrina; Montag, Dirk; Budinger, Eike; Angenstein, Frank; Fejtova, Anna; Tischmeyer, Wolfgang; Gundelfinger, Eckart D.; Stork, Oliver
In: Brain structure & function - Berlin : Springer, Bd. 223 (2018), Heft 7, S. 3423-3445
2017
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Raza, Ahsan Syed; Albrecht, Anne; Çalişkan, Gürsel; Müller, Bettina; Demiray, Yunus Emre; Ludewig, Susann; Meis, Susanne; Faber, Nicolai; Hartig, Roland; Schraven, Burkhart; Leßmann, Volkmar; Schwegler, Herbert; Stork, Oliver
In: Nature Communications - [London] : Nature Publishing Group UK - Vol. 8.2017, Art. 189, insgesamt 15 S.
Neurobiological consequences of juvenile stress - a GABAergic perspective on risk and resilience
Albrecht, Anne; Müller, Iris; Ardi, Ziv; Çalışkan, Gürsel; Gruber, David; Ivens, Sebastian; Segal, Menahem; Behr, Joachim; Heinemann, Uwe; Stork, Oliver; Richter-Levin, Gal
In: Neuroscience & biobehavioral reviews: official journal of the International Behavioral Neuroscience Society - Amsterdam [u.a.]: Elsevier Science - official journal of the International Behavioral Neuroscience Society, Vol. 74.2017, Part A, S. 21-43
2016
Identification of parvalbumin interneurons as cellular substrate of fear memory persistence
Çalişkan, Gürsel; Müller, Iris; Semtner, Marcus; Winkelmann, Aline; Raza, Ahsan Syed; Hollnagel, Jan O.; Rösler, Anton; Heinemann, Uwe; Stork, Oliver; Meier, Jochen C.
In: Cerebral cortex - Oxford: Oxford Univ. Press, Bd. 26 (2016), 5, S. 2325-2340
Shifts in excitatory/inhibitory balance by juvenile stress - a role for neuron-astrocyte interaction in the dentate gyrus
Albrecht, Anne; Ivens, Sebastian; Papageorgiou, Ismini E.; Çalişkan, Gürsel; Saiepour, Nasrin; Brück, Wolfgang; Richter-Levin, Gal; Heinemann, Uwe; Stork, Oliver
In: Glia - Bognor Regis [u.a.]: Wiley-Liss, Bd. 64 (2016), 6, S. 911-922
2015
The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology
Müller, Iris; Çalışkan, Gürsel; Stork, Oliver
In: Genes, brain and behavior: official journal of IBANGS - International Behavioural and Neural Genetics Society - Copenhagen [u.a.]: Blackwell Munksgaard, 2002, Bd. 14.2015, 1, S. 37-45
2013
Long-lasting increase of corticosterone after fear memory reactivation - anxiolytic effects and network activity modulation in the ventral hippocampus
Albrecht, Anne; Çalişkan, Gürsel; Oitzl, Melly S.; Heinemann, Uwe; Stork, Oliver
In: Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology - London: Springer Nature - official publication of the American College of Neuropsychopharmacology, Bd. 38 (2013), 3, S. 386-394
2011
Histaminergic modulation of acetylcholine-induced γ oscillations in rat hippocampus
Fano, Silvia; Caliskan, Gürsel; Behrens, Christoph J.; Heinemann, Uwe
In: Neuroreport - London: Lippincott Williams & Wilkins, Bd. 22 (2020), 11, S. 520-524, 2011