Abteilung für Genetik &

Molekulare Neurobiologie

1. Barnstedt, O, Mocellin P, Remy S. 2023. A hippocampus-accumbens code guides goal-directed appetitive behavior. BioRxiv, 2023.03.09.531869. doi.org/10.1101/2023.03.09.531869. In revision.
In the top 5% of all research outputs scored by Altmetric; highlighted by Simons Foundation on May 16, 2023.
The dorsal hippocampus (dHPC) is a major centre for processing spatial memories, but the role of its downstream path- ways remains unclear. We have used dual-colour 2-photon imaging and optogenetics to show special coding character- istics of nucleus accumbens-projecting neurons that allow mice to engage in goal-directed behaviour upon approach of a learned reward zone.

2. Barnstedt O, Owald D, Felsenberg J, Brain R, Moszynski J, Talbot CB, Perrat P, Waddell S. 2016. Memory-Relevant Mush- room Body Output Synapses Are Cholinergic.
Neuron, 89(6): 1237–1247. doi.org/10.1016/j.neuron.2016.02.015.
JIF: 18.7, Citations: 171.

The mushroom body (MB) is the main learning and memory centre of invertebrate brains, but its main neurotransmitter has remained a mystery before this publication. Using a combination of histological, behavioural, optogenetic, and 1P/2P calcium imaging methods, we conclusively demonstrate acetylcholine as the main MB transmitter used for communica- tion with MB output neurons. This shows that structural plasticity at a cholinergic synapse underlies olfactory associative learning in Drosophila.

3. Barnstedt O, Keating P, Weissenberger Y, King AJ, Dahmen JC. 2015. Functional Microarchitecture of the Mouse Dorsal Inferior Colliculus Revealed through In Vivo Two-Photon Calcium Imaging.
Journal of Neuroscience, 35(31): 10927–10939. doi.org/10.1523/jneurosci.0103-15.2015.
JIF: 6.7, Citations: 66.

This work represents the first 2-photon calcium imaging study of the mammalian midbrain, and describes tonotopic re- sponses in somata of inferior colliculus neurons as well as in axonal projections from auditory cortex.

weitere begutachtete Zeitschriftenartikel

4. Felsenberg J, Jacob PF, Walker T, Barnstedt O, Edmondson-Stait AJ, Pleijzier MW, Otto N, Schlegel P, Sharifi N, Perisse E, Smith CS, Lauritzen JS, Costa M, Jefferis GSXE, Bock DD, Waddell S. 2018. Integration of parallel opposing memories underlies memory extinction.
Cell, 175 (3): 709-722. doi.org/10.1016/j.cell.2018.08.021.

JIF: 66.9, Citations: 160.

5. Felsenberg J, Barnstedt O, Cognigni P, Lin S, Waddell S. 2017. Re-evaluation of learned information in Drosophila. Nature, 544(7649): 240-244. doi.org/10.1038/nature21716.
JIF: 69.5, Citations: 119.

6. Žurauskas M, Barnstedt O, Frade-Rodriguez M, Waddell S, Booth MJ. 2017. Rapid adaptive remote focusing microscope for sensing of volumetric neural activity.
Biomedical optics express, 8(10): 4369-4379. doi.org/10.1364/boe.8.004369.
JIF: 3.6, Citations: 54.

7. Perisse E*, Owald D*, Barnstedt O, Talbot CB, Huetteroth W, Waddell S. 2016. Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body.
Neuron, 90(5): 1086-1099. doi.org/10.1016/j.neuron.2016.04.034.
JIF: 18.7, Citations: 159.

begutachtete Artikel

8. Waddell S, Barnstedt O, Treiber C. 2014. Neural Transposition in the Drosophila Brain: Is It All Bad News?
Advances in Genetics, 86(65). Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans. doi.org/10.1016/B978- 0-12-800222-3.00004-8.

OTHER MANUSCRIPTS

9. Mocellin P, Barnstedt O, Luxem K, Kaneko H, Mikulovic S, Remy S. A septal-VTA circuit drives exploratory behavior. In

revision.
10. Barnstedt O, Mocellin P, Pakan J, Musall S, Remy S. MouseFlow: A Python toolbox for automated facial and bodily

movement detection in head-fixed mice. In preparation.