Network Activity of Fear
Oscillatory network rhythms are critical means for the interregional communication in the brain; they control information transfer, information filtering and synaptic plasticity in different behavioral states. In the hippocampus, two types of rhythms, gamma oscillations and sharp-wave ripples are generated, depending on the the level of cholinergic activation. We have identified molecular and cellular mechanisms that control the generation and propagation of these rhythms and their modulation by fear and anxiety.
Publications
Çalışkan G, Stork O. A Hippocampal network oscillations at the interplay between innate anxiety and learned fear. Psychopharmacology (Berl). 2019; 236(1):321-338
Çalışkan G, Stork O. Hippocampal network oscillations as mediators of behavioural metaplasticity: insights from emotional learning. Neurobiol Learn Mem. 2018; 154:37-53.
Çalışkan G, Müller I, Semtner M, Winkelmann A, Raza AS, Hollnagel JO, Rösler A, Heinemann U, Stork O, Meier JC. Identification of Parvalbumin Interneurons as Cellular Substrate of Fear Memory Persistence. Cereb Cortex. 2016 May;26(5):2325-40.
Caliskan, G., Albrecht, A., Hollnagel, J. O., Rosler, A., Richter-Levin, G., Heinemann, U., & Stork, O. (2015). Long-term changes in the CA3 associative network of fear-conditioned mice. Stress (Amsterdam, Netherlands), 1–32. doi:10.3109/10253890.2015.1004628
Funding
CBBS Science Campus, project group 6 
PIs: Dr. Gürsel Çalişkan, Prof. Dr. Oliver Stork
Researcher: M.Sc. Sara Enrile
CBBS NeuroNetwork: CBBScircuitS – A Neuronetwork for functional analysis of the engram connectome
PIs: Dr. Gürsel Çalışkan, Anne Bayrhammer (IPT), Guilherme Monteiro Gomes (LIN)